Appendix 2. Coagulation Factors

(From AABB Technical Manual, ed. 14. In press. Courtesy Mark Brecher, MD, editor)

Factor Name In vivo
Half-life		 In vitro,
4 deg C
Half-life		 % of Normal 
Needed for 
Hemostasis		 % In Vivo Recovery Initial Therapeutic Dose
I Fibrinogen
3-6 days
Years
12-50
50-70
 1 bag cryoprecipitate/7 kg body weight
II Prothrombin
2-5 days
> 21 d.
10-25
50
 10-20 units//kg body weight
V Labile factor, Proaccelerin
4.5-36 hours
10-14 d.
10-30
Approx.. 80
 10-20 mL plasma/kg body weight
VII Stable factor, Proconvertin
1-7 hours
> 21 d.
> 10
100
 10-20 units/kg body weight
VIII Anti-hemophilic factor
8-12 hours
7 d.
30-100
60-70
 15-50 units/kg body weight
IX Plasma thromboplastin component, Christmas factor
12-24 hours
> 21 d.
30-80
20
 30-80 units/kg body weight
X Stuart-Prower factor
20-50 hours
> 21 d.
10-40
50-95
 10-20 units/kg body weight
XI Plasma thromboplastin antecedent (PTA)
40-80 hours
3-4 d.
20-30
90
 10-20 ml plasma/kg body weight
XIII Fibrin-stabilizing factor
3-12 days
> 21 d.
< 5
50-100
 500 ml plasma every 3 weeks
AT III Antithrombin III
60-90 hours
> 42 d.
80-120
50-100
 40-50 IU/kg body weight
 
Note:
1. All dosings are provided as a general guideline for initial therapy, the exact loading dose and maintenance intervals should be individualized for each patient.
2. One unit of coagulation factor is present in each ml of fresh-frozen plasma. 
3. DDAVP is the treatment of choice for patients with hemophilia A who are responders.
 
Composite data from the following references:
Beutler E, Lichman MA, Coller BS, Kipps TL, eds. Williams' hematology, 5th ed. New York: McGraw-Hill, 1995:1413-58, 1657
Mollison PL, Engelfreit CP, Contreras M. Blood transfusion in clinical medicine. 9th ed. Oxford:Blackwell Scientific Publications, 1993:657-69
Huestis DW, Bove JR, Case J, eds. Practical Blood Transfuson. Fourth Edition. Little Brown and Co. Page 1988:319
Counts RB, Haisch C, Simon TL, Maxwell NG, Heimbach DM, Carrico CJ. Hemostasis in Massivly Transfused Trauma Patients. Annals Surg 190;1979:91-99.
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Posted:  Sept. 24, 2001