Use of liquid plasma for resuscitation of actively bleeding trauma patients

Do any hospitals, other than Stanford University Hospital, manage the resuscitation of actively bleeding trauma patients with liquid plasma, rather than FFP, FP24 or other thawed frozen plasma products?

Editors' Note: According to a recently published letter to the editor of Transfusion Medicine Reviews, Stanford University Hospital uses their own liquid plasma inventory for emergencies requiring immediate plasma therapy. Their plasma source is the Stanford Blood Center, which provides plasma products from male donors. Liquid plasma is removed from a whole blood donation and is stored and refrigerated at 1°C to 6°C, rather than frozen as is FP24. Stanford University Hospital takes advantage of the fact that liquid plasma is an FDA-approved product and can be stored refrigerated for up to 26 days. Because liquid plasma has never been frozen, the product contains intact white blood cells and is therefore not regarded as cytomegalovirus safe and would also need to be irradiated for immunosuppressed patients. Consequently, Stanford University Hospital uses an irradiated liquid plasma inventory. The Stanford University Hospital Transfusion Committee has agreed that cytomegalovirus status is not relevant for emergency clinical settings in which the benefit of immediate plasma therapy is recognized, such as for level 1 trauma, postpartum hemorrhage and emergency reversal of warfarin.

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