Handling an HBsAg Positive, NAT negative Donor
John Bowers, Senior Medical Technologist at Mercy Medical Center in Springfield, MA (attribution used with permission) asks how other facilities would handle a blood donor who has a persistently positive (repeat reactive) test for HBsAg, but is neutralization assay negative as well as negative for HBV NAT and anti-HBc antibody. The donor has had positive HBsAg screens 8 months apart. The donor was vaccinated against HBV approximately four years prior.
The following FDA Guidance documents may apply:
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