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Management of other components from a donation when red cells fail leukocyte reduction filtration

A medical director at a medium-sized donor center wonders how other centers manage blood components such as FFP and Cryoprecipitate when a blood donation fails leukocyte reduction filtration. The medical director acknowledges that their local policy is to investigate the cause of each failure, recognizing that most leukoreduction failures occur due to the donor having sickle cell trait, and to prepare FFP and Cryoprecipitate if a donor has sickle cell trait. They base their policy (without providing data) on a belief that if the donor has sickle cell trait, the abnormal red cells should not negatively impact the quality of FFP or cryoprecipitate, nor should the filtration process if it fails. Do other centers handle this differently or have data regarding the impact of failed leukocyte reduction filtration on any plasma components if they are produced from such a donation?

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Ira A. Shulman, MD
CBBS e-Network Forum Editor & Moderator

W. Tait Stevens, MD
CBBS e-Network Forum Assistant Editor & Moderator
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Posted:October 16, 2006

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