Pre-infusion crossmatching of heparinized allogeneic bone marrow

A blood banker in a sunbelt state wonders if any e-network forum colleagues have information about pre-infusion crossmatching of heparinized allogenic bone marrow. Specifically, she wants to know about experiences with pre-bone marrow infusion compatibility testing for detection of ABO or other serologic incompatibilities between allogeneic marrow and the intended recipient, and what problems, if any, have been encountered with this kind of pre-infusion compatibility testing? The inquiring blood banker said that the bone marrow containers at her institution have segments attached, and that the cells from these segments can be used for an immediate spin or antiglobulin crossmatch between the heparinized bone marrow and the serum (or plasma) of the intended marrow recipient.

Editor's comment: Several colleagues who subscribe to the e-network forum work at FACT-accredited institutions. It would be particularly interesting to receive comments from those members.

Submit comments to the e-Network Forum at enetworkforum@cbbsweb.org

Ira A. Shulman, MD
CBBS e-Network Forum Senior Editor & Moderator

W. Tait Stevens, MD
CBBS e-Network Forum Editor & Moderator

Elizabeth M. St. Lezin, MD
CBBS e-Network Forum Associate Editor & Moderator

The e-Network Forum is supported in part by the California Blood Bank Society (CBBS) and the American Red Cross Blood Services (ARCBS) and endorses collegial discussion among blood banking and transfusion medicine professionals. However, neither the CBBS nor the ARCBS in any way endorse the specific views and opinions expressed in the forum. The forum is not intended as a substitute for medical or legal advice and the content should not be relied upon for any medical or legal purposes. Readers should make their own determinations as to: (i) what constitutes appropriate medical, technical, and administrative practices, and (ii) how best to comply with laws and regulations relevant to their questions. For the latter, they should consider consulting, as to any medical matters, a qualified physician, and, as to any legal matters, an attorney familiar with related state and federal laws. The user of the forum, by accessing same, assumes all risks arising out of such use and releases CBBS and their respective members, directors, officers and agents from and against any loss, damage, claim or liab